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KMID : 1161420150180030385
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Journal of Medicinal Food
2015 Volume.18 No. 3 p.385 ~ p.391
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Antidiabetic and Antilipidemic Effects of Manilkara zapota
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Barbalho Sandra Maria
dos Santos Bueno Patricia Cincotto
Delazari Debora Souza
Guiguer Elen Landgraf
Coqueiro Daniel Pereira
Araujo Adriano Cressoni
de Souza Maricelma da Silva Soares
Farinazzi-Machado Flavia M. V.
Mendes Claudemir Gregorio
Groppo Milton
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Abstract
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Manilkara zapota is a tropical evergreen tree belonging to the Sapotaceae family; its parts are used in alternative medicine to treat coughs and colds and possess diuretic, antidiarrheal, antibiotic, antihyperglycemic, and hypocholesterolemic effects. There are no studies on metabolic profile after using the fruit, and this study aimed at evaluating the effects of the leaf and pulp of M. zapota fruit on the metabolic profile of Wistar rats. Male rats were treated for 50 days with M. zapota leaf juice or fruit juice, after which their biochemical and body composition profiles were analyzed (glycemia, triglycerides, high-density lipoprotein cholesterol (HDL-c), insulin, leptin, aspartate transaminase, alanine aminotransferase, Lee Index, and body mass index). Our results indicate significantly lower levels of glycemia, insulin, leptin, cholesterol, and triglycerides and augmented levels of HDL-c in animals treated with the leaves or fruit of this plant. The percentage of weight gain also declined in animals treated with M. zapota fruit pulp. The use of the M. zapota may be helpful in the prevention of obesity, diabetes, dyslipidemia, and their complications.
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KEYWORD
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glycemia, insulin, leptin, lipids, Manilkara zapota, Wistar rats
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